Immune System
Optimal Result: 69.2 - 273.6 ng/mL.
Interpret your laboratory results now.
C3 is the most abundant protein of the complement system. C3 can be cleaved in two divalent fragments, where C3b is the larger fragment. C3a is the smaller fragment that is released into the surrounding fluids. C3a can bind to receptors on basophils and mast cells triggering them to release their vasoactive amines (e.g. histamine). Because of the role of these biomarkers in anaphylaxis, C3a is called an anaphylatoxin. C3a is one of the most potent constrictors of smooth muscle cells. C3a has been shown to be a multifunctional pro-inflammatory mediator.
- C3a may be an indicator of a Lyme-related issue if the Lyme is in an acute stage.
- Although C3a was shown to be elevated in a cohort of early, acute Lyme disease patients, it appears to be normal in chronic Lyme patients.
- In mold, C3a is normal and C4a is high.
References:
- https://www.ncbi.nlm.nih.gov/pubmed/18270493
- https://www.ncbi.nlm.nih.gov/pubmed/19140878
- https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.1780290905
- https://www.ncbi.nlm.nih.gov/pubmed/3263085
- https://www.karger.com/Article/FullText/328238
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1959484/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753731/
- https://www.ncbi.nlm.nih.gov/pubmed/16586433
- https://www.ncbi.nlm.nih.gov/pubmed/20012107
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532535/
- https://www.ncbi.nlm.nih.gov/pubmed/25520093
- https://www.ncbi.nlm.nih.gov/pubmed/19601884
- https://www.ncbi.nlm.nih.gov/pubmed/21615487
- https://jacewellness.com/articles/Lab%20Testing%20for%20water%20damaged%20building%20illness.pdf
- https://www.survivingmold.com/docs/Resources/Shoemaker%20Papers/Lyme_acute_C4a_1_08_glovsky.pdf
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What does it mean if your Complement C3a result is too high?
Complement C3a was found to be elevated in patients with:
- Inflammation (such as asthma)
- Autoimmune diseases [C3a levels were increased in patients with severe and moderately active lupus(SLE).]
- Chronic hepatitis C, and HCV-related hepatitis cell carcinoma.
- In a recent study, all acute Lyme disease patients had elevated levels of C3a, hence C3a (and C4a) can be regarded as an early marker of acute lyme disease in patients seen shortly after tick bite.
- Smoking
- Stroke
- Chronic hepatitis/liver cancer
- Colon cancer
- Pancreas inflammation
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What does it mean if your Complement C3a result is too low?
Low C3a levels may increase the risk of infections and inflammation.
- An inherited deficiency of C3 predisposes patients to frequent bouts of bacterial infections.
- Gestational Diabetes - this occurs when healthy women develop high blood sugar levels during pregnancy.
Although C3a was shown to be elevated in a cohort of early, acute Lyme disease patients, it appears to be normal in chronic Lyme patients.
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Frequently asked questions
Unlock Your Health Journey with Healthmatters.io! Ever wished for a one-stop digital health haven for all your lab tests? Look no further! Healthmatters.io is your personalized health dashboard, bringing together test reports from any lab. Say goodbye to scattered results—organize and centralize your lab data effortlessly. Dive into the details of each biomarker and gain insights into the meaning behind your medical test data.
Join the community of thousands who've transformed the way they understand their lab results. Experience the joy of having all your lab data neatly organized, regardless of where or when the tests were done.
For our professional users, Healthmatters.io is a game-changer. Revel in the intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history. It's not just a dashboard; it's your gateway to a smarter, more informed health journey!
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If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we do talk about popular labs, we welcome reports from lots of other places too. It's as simple as this: if you can get a test done, you can upload it to Healthmatters. We can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
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For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you. We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.
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Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
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Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
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