Anti-Complement C3 Antibodies | Invitrogen (2024)

FAQs

What does it mean when complement C3 is high? ›

4. What does it mean if your complement C3 is high? Higher-than-normal or elevated C3 levels indicate that the immune system is active right after an infection or injury. Higher levels could also indicate complex conditions such as diabetes, heart attack, cancer, leukaemia, or ulcerative colitis.

High C3 complement levels indicate inflammation in the body. The inflammation could be due to ulcerative colitis or other acute diseases like sarcoma, leukemia, or Hodgkin's Lymphoma. These are all different types of cancer. However, increased levels of C3 are not the main indication of cancer.

Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate: comparison study in an elderly population.

Anti-C3 antibodies are used in the immunodetection of the protein complement C3. In humans, the canonical protein has a reported length of 1663 amino acid residues and a mass of 187.1 kDa. It has been described to be a secreted protein. It is notably expressed in plasma.

One of the diseases that often causes abnormal C3 is systemic lupus erythematosus (SLE). Lupus is an autoimmune disorder.

Low C3 and C4 levels (below 60 for C3 and below 15 for C4 in the usual American measure), occur in active lupus, especially when the kidneys are affected or there is immune breakdown of blood cells (autoimmune hemolytic anemia, AIHA).

C3 fixation and activation was greater in the presence of serum from patients with Hashimoto's disease when compared with that seen in patients with autoimmune hyperthyroidism (Graves' disease). Serum samples obtained from normal healthy volunteers and from patients with thyroid neoplasia were negative in this assay.

When the complement system is turned on during inflammation, levels of complement proteins may go down. For example, people with active lupus erythematosus may have lower-than-normal levels of the complement proteins C3 and C4. The test may also be done for the following conditions: Fungal infections.

C3 levels were also significantly elevated in the CSF of patients with progressive MS (35) and soluble C5b-C9 terminal complexes were also increased in the CSF of MS patients (36).

Because synovial fluid levels of the C3 anaphylatoxins, C3a and C3a desArg, are more than 7 times higher in patients with rheumatoid arthritis (RA) than in patients with degenerative joint disease or traumatic arthritis, we conducted a prospective study of plasma levels of C3 and C5 anaphylatoxins in 11 RA patients.

What happens if C3 and C4 are high? ›

Activation of complement factors may be an important part of inflammatory processes, and our results indicated that the elevated C3 and C4 levels were independent risk factors for MetS development.

The three most commonly used inflammatory markers are called C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and plasma viscosity (PV).

What do high levels of C3 mean? Higher-than-normal levels of C3 proteins can indicate that you've just had an infection and your immune system is responding to it. If you're getting treatment for lupus or another autoimmune disease, higher levels of C3 proteins usually mean that treatment is working.

Inherited C3 deficiency results in repeated, severe infections starting from birth, especially those of the respiratory tract. Organisms such as Streptococcus pneumoniae and Hemophilus influenzae are the most frequent causes of infection.

The complement system can be activated by three different pathways, including the classical pathway, lectin pathway, and alternative pathway (1, 4, 5). C3 is a center factor in the complement system, all three complement activation pathways converge in C3 and formation of C5 convertase (6).

What does it mean if your Complement C3a result is too high? Complement C3a was found to be elevated in patients with: - Inflammation (such as asthma) - Autoimmune diseases [C3a levels were increased in patients with severe and moderately active lupus (SLE).]